DIPROCORT-MF OINTMENT
DESCRIPTION :
DIPROCORT-MF ointment contains the active compound clobetasol propionate, a
synthetic corticosteroid and salicylic acid, a keratolytic agent, for topical dermatologic use and
moisturizing factors Urea, Lactic acid & sodium lactate.
Clobetasol is an analog of prednisolone having a high degree of glucocorticoid activity and a slight degree
of mineralocorticoid activity.
Salicylic acid is a keratolytic and antiseptic agent.
ACTIONS :
The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear.
It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as
prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid.
Corticosteroids are also thought to act by the induction of phospholipase A2 inhibitory proteins.
Topical salicylic acid has keratolytic properties as well as bacteriostatic and fungicidal actions.
: Topical corticosteroids can be absorbed from normal intact skin. The extent of
percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle
and the integrity of the epidermal barrier. Inflammation and/or other disease processes in the skin may
increase percutaneous absorption.
INDICATIONS AND USAGE
: DIPROCORT-MF Ointment is super-high potency corticosteroid
formulation indicated for the relief of the inflammatory manifestations of hyperkeratotic and dry
corticosteroid-responsive dermatoses such as :
Psoriasis,
Chronic atopic dermatitis,
Neurodermatitis (lichen simplex chronicus),
Lichen planus,
Eczema (including nummular eczema, hand eczema, eczematous dermatitis),
Dyshidrosis (pompholyx),
Seborrheic dermatitis of the scalp,
Ichthyosis vulgaris and other ichthyotic conditions.
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